PhenoVision Bio Co., ltd
Every cell is not an island
The rapid development of multiplex immunofluorescence (mIF) technology has made it possible to decode more secrets of the tissue microenvironment at the single-cell level in situ. After obtaining high-quality mIF staining results, how to decipher and interpret these results is the next important issue to be faced. Phenovision has introduced the leading image analysis artificial intelligence algorithm of Visiopharm to generate the “Phenovision Whole Slide Analysis (PWSA) Platform”, which mines the rich data information of whole slide scanning images to deeply interpret the tissue microenvironment and spatial biology information.
Multiplex immunofluorescence assay service
Human tonsil, mIF staining images
Human endometrial cancer, mIF staining images
A wide range of spatial multi-omics technologies are available, from high-throughput spatial transcriptomics and proteomics to low-throughput RNA in situ detection techniques and multiplex fluorescence immunohistochemistry (IHC) methods. Each of these methodologies plays a unique role in its respective application area.PhenoVision Bio Co., Itd (菲诺维康) possesses an advanced spatial multi-omics platform and downstream data analysis platform. Backed by a team of experienced professionals with years of expertise in this field, PhenoVision integrates R&D, laboratory services, and clinical application development. It offers a one-stop spatial biology solution for multi-omics (DNA, RNA, and protein) analysis.
Histopathology Technical Service
Organoid paraffin preparation and staining staining
Drosophila brain FFPE preparation and H&E staining
Human cervical scraped cell FFPE preparation and RNAscope tests
human bone decalfication and RNAscope
Publications
1️⃣ Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
Authors: Yong Jiang, Anran Dai, Yuwei Huang, et al.
Affiliation: ShanghaiTech University; Shanghai Institute of Biochemistry and Cell Biology, CAS; University of Pittsburgh School of Medicine & UPMC Hillman Cancer Center; Peking University Cancer Hospital & Research Institute; BeiGene, Ltd
Journal: Cell
Date: May 2025 (epub 17 Mar 2025)
DOI: 10.1016/j.cell.2025.02.014
2️⃣ Lysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration
Authors: Yuan-Yuan Li, Bo Ma, Jia-Wei Lu, et al.
Affiliation: State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University; Xiamen University Affiliated Chenggong Hospital; Laboratory of Toxicant Analysis, Academy of Military Medical Sciences
Journal: Advanced Science
Date: September 2025 (epub 23 Jun 2025)
DOI: 10.1002/advs.202505070
3️⃣ Single-nucleus RNA sequencing and spatial transcriptomics reveal an immunosuppressive tumor microenvironment related to metastatic dissemination during pancreatic cancer liver metastasis
Authors: Hongsen Liu, Mengting Chen, Yun Qian, et al.
Affiliation: Stomatology Hospital & School of Stomatology, Zhejiang University School of Medicine; Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine
Journal: Theranostics
Date: April 2025
DOI: 10.7150/thno.108925
4️⃣ Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases
Authors: Wei Guo, Bolun Zhou, Lizhou Dou, et al.
Affiliation: National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Journal: Experimental & Molecular Medicine
Date: February 2025
DOI: 10.1038/s12276-024-01369-x
5️⃣ Anlotinib plus TQB2450, a PD-L1 Antibody, in Patients with Advanced Alveolar Soft Part Sarcoma: A Single-Arm, Phase II Trial
Authors: Zhichao Tan, Yan Wu, Zhengfu Fan, et al.
Affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute; Musculoskeletal Tumor Center, Peking University People’s Hospital
Journal: Clinical Cancer Research
Date: December 2024
DOI: 10.1158/1078-0432.CCR-24-2444
6️⃣ Tertiary lymphoid structures correlate with the therapeutic efficacy and prognosis of resectable esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy plus immunotherapy
Authors: Ke Zhai, Ru Xie, Kun Ru, et al.
Affiliation: Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences
Journal: Frontiers in Immunology
Date: August 2025
DOI: 10.3389/fimmu.2025.1616247
7️⃣ Integrating scRNA-seq and spatial transcriptomics to explore the implication of G6PD on immune microenvironment in lymphatic metastasis of breast cancer
Authors: Hongsen Liu, Mengting Chen, Bo Hong, et al.
Affiliation: Stomatology Hospital & School of Stomatology, Zhejiang University School of Medicine; Cancer Center of Zhejiang University; Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine
Journal: Medical Oncology
Date: July 2025
DOI: 10.1007/s12032-025-02943-7
8️⃣“Young-Mechanical Niche” biomimetic hydrogel promotes dental pulp regeneration through YAP-dependent mechanotransduction
Authors: Zibin Zhang, Changfang Li, Jia Guo, et al.
Affiliation: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University; Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi’an Jiaotong University
Journal: Chemical Engineering Journal
Date: November 2024 (Available online 7 November 2024)
DOI: 10.1016/j.cej.2024.157483
