Focus on creating a one-stop space biology solution for multi-application scenarios
Application scenario
Multiple immune cell types co detection
Application scenario
Spatial phenotypic analysis of tissue microenvironment – tertiary lymphoid structure
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs formed from non-lymphoid tissue during chronic inflammation and tumor. They are composed of T cells, B cells, follicular dendritic cells, etc. TLSs exist in tumor tissues in different mature states. The highest level can form a germinal center structure. In recent years, a number of well-known teams have conducted in-depth studies on the correlation between TLSs and tumors. It was found that B-cell infiltration and the formation of tertiary lymphoid structure in different tumor types were positively correlated with patients’ response to immunotherapy, which emphasized the important role of B-cells and TLSs in anti-tumor immunity.
Science.2022 Jan 7;375(6576)
Tertiary lymph nodes (TLSs) detected in human melanoma samples using 7-color fluorescence immunohistochemistry kit (PhenoVision Bio Co., Itd)
Application scenarios
1. Evaluation of immunotherapy efficacy
1. Evaluation of immunotherapy efficacy
Compared with NGS, RNA-seq, immunohistochemistry and other methodologies, the evaluation of immune therapy is more accurate.
2. Immune-polyvalent drug testing
· Clinical PD-L1 combined with CTLA-4 neoadjuvant therapy
· ·PD-L1, CTLA-4, CD20, and CD8 were used to evaluate immunotherapy efficacy in patients
3. Molecular typing of diseases
According to the expression of tumor tissue PD-L1 and tumor infiltrating lymphocytes (TIL), tumors can be divided into 4 immune phenotypes, and Type II is the ideal type of PD-1/PD-L1 inhibitor.
